欧贤红副教授—硕导
欧贤红，副教授, 硕士生导师。2008-2011年毕业于广西医科大学，获药理学博士学位。2013-2016年于浙江大学博士后流动站西南医科大学工作站开展博士后研究，方向为心律失常发病机制及防治策略。2017年至今就职于西南医科大学心血管医学研究所。曾赴北京大学、英国访学。近几年主持国家自然科学基金、省科技厅项目、中国博士后基金等各层次项目共10余项。在国内外期刊发表论著近90篇，其中SCI收录24篇，参编《自主神经与心血管疾病》等专著3部，授权国家发明专利1项。获国家基础医学创新大赛（A类）“优秀指导老师”。任Sci Data期刊编辑，Adv Sci、Life Sci等期刊审稿人。
研究方向：
1、心血管药理学；
2、心律失常发病机制及防治策略
一、近年承担主要课题
1. 基于CaMKII/INaL靶点研究丹参、附子有效单体复合物对心肌缺血再灌注心律失常的作用，四川省科技厅重点研发项目，2024YFFK0180，2024.07.01-2026.06.30，主持
2. 应激诱导“Pnmt细胞分化的心肌细胞”分泌肾上腺素对小鼠心肌细胞兴奋-收缩偶联钙转运的调控作用，国家自然科学基金青年基金，2018.1-2020.12，No.81700308，主持
3. Pnmt+心肌细胞串扰局部肾上腺能信号参与应激性心肌病的机制，四川省科技厅，2021.4.1-2023.3.30, No.21YYJC1944，主持
4. Pnmt+心肌细胞与心脏交感神经的相互关系, 代谢及心血管分子医学北京市重点实验室开放课题, 2018.1.1-2018.12.30，主持
5. Pnmt+心肌细胞对心脏交感神经细胞的反馈调控及机理研究, 国家自然科学基金面上项目, 2019.1-2022.12，No.31871181，主要参与者
6. PAK 激动剂治疗CPVT的效果和机理探索研究,四川省科技厅骈骥项目，2025.1.1-2026.12.30，主要参与者
7. “肠-心-脑轴”对米诺环素改善小鼠心肌梗死合并抑郁障碍的作用及机制研究, 四川省科技厅面上项目，2025.1.1-2026.12.30, 主要参与者
二、近五年发表的主要论文
1. Dan Zhang#, Qiang Wen#, Kou Ku, Rui Zhang, Miao Lin, Shiyu Zhang, Jun Yang, Hangchuan Shi, Xiaoqiu Tan*, Shigang Yin*, Xianhong Ou *. From Cell to Gene: deciphering the Mechanism of heart failure with Single-cell Sequencing. Adv Sci (Weinh). 2024 Oct;11(39):e2308900. IF 14.3
2. Li T, Liu T, Wang Y, Li Y, Liu L, Bae J, He Y, Luo X, Liu Z, Chen T, Ou X, Zhang D, Lan H, Wan J, Wei Y, Zhao F, Wang X, Li T, Huang CL, Zhang C, Lei M, Tan X. P21-Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy. Adv Sci (Weinh). 2025 Mar 11:e2411987. IF 14.3
3. Lin M#, Zhang S#, Zhang L#, Yang C, Luo Y, Peng Y, Tan X, Wen Q*, Fan X*, Ou X*. Redefining outcomes of ventricular arrhythmia for SGLT2 inhibitor medication in heart failure patients: a meta-analysis of randomized controlled trials. Syst Rev. 2025 Feb 1;14(1):31. IF 6.3
4. Qiang Wen#, Rui Zhang#, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L-H Huang*, Xianhong Ou*. Empagliflozin attenuates cardiac remodeling in murine cardiac failure induced by transverse aortic coarctation through calmodulin kinase II mediated actions on Nav1.5. Sci Rep, Sci Rep, 2024 Jul 8;14(1):15683.
5. Tianyi Sun#, Alexander Grassam-Rowe#, Zhaoli Pu#, Huiying Ren, Yanru An, Xinyu Guo, Wei Hu, Ying Liu, Yangpeng Li, Zhu Liu, Kun Kou, Xianhong Ou , Tangting Chen, Xuehui Fan, Yangyang Liu , Tu Shu , Yu He , Yue Ren , Ao Chen , Zhouchun Shang Zhidao Xia, Lucile Miquerol , Nicola Smart, Henggui Zhang, Xiaoqiu Tan* , Weinian Shou* , Ming Lei*. Integrated transcriptome and lineage analyses reveal Dbh+ catecholaminergic cardiomyocytes contributing to the cardiac conduction system in murine heart. Nature Communication,2023, 14(1):7801, IF 17.694
6. Tianyi Sun#, Alexander Grassam-Rowe#, Zhaoli Pu#, Huiying Ren , Yanru An, Xinyu Guo , Wei Hu, Ying Liu, Yangpeng Li, Zhu Liu, Kun Kou, Xianhong Ou , Tangting Chen, Xuehui Fan, Yangyang Liu , Tu Shu , Yu He , Yue Ren , Ao Chen , Zhouchun Shang Zhidao Xia, Lucile Miquerol, Nicola Smart, Henggui Zhang, Xiaoqiu Tan*, Weinian Shou*, Ming Lei*. Integrated transcriptome and lineage analyses reveal Dbh+ catecholaminergic cardiomyocytes contributing to the cardiac conduction system in murine heart. Nature Communication. 2023, https://doi.org/10.1038/s41467-023-42658-9
7. Huiying Ren, Xiaolin Zhou, Jun Yang, Kun Kou, Tangting Chen, Zhaoli Pu, Kejun Ye, Xuehui Fan, Dan Zhang, Xinjiang Kang, Zhongcai Fan, Ming Lei, Tianyi Sun, Xiaoqiu Tan，Xianhong Ou. Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system, Sci Data. 2023 Sep 4;10(1):577
8. Yang J#, Ye K#, Zhang R, Fan X, Xiong R, Zhang S, Liu Q, Lin M, Wang B, Tan X*, Wen Q*, Ou X*. The characteristics and molecular targets of antiarrhythmic natural products. Biomed Pharmacother. 2023,168:115762.
9. Yangpeng Li1*, Jun Yang1*, Rui Zhang1, Tangting Chen1, Shiyu Zhang1, Yuqing Zheng1,Qiang Wen2, Tao Li1, Xiaoqiu Tan1†, Ming Lei1,3†, Xianhong Ou1†. Dual-dye optical mapping of mouse hearts with genetic catecholaminergic polymorphic ventricular tachycardia. JOVE, Dec 22, 2023 doi: 10.3791/65082.
10. Jun S, Ou X, Shi L, Yu H, Deng T, Chen J, Nie X, Hao Y, Shi Y, Liu W, Tian Y, Wang S, Yuan F. Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons. NEUROSCIENCE BULLETIN. 2023;39(8):1193-1209.
11. He S†, Kou K†, O’Shea C†, Chen T, Mu-u-min R, Dong R,Ren H. Zhou X, Fan Z, Tan X, Pavlovic D‡, Ou X‡, Lei M*‡. A dataset of dual calcium and voltage optical mapping in healthy and hypertrophied murine hearts. Sci Data. 2021: 314
12. 叶珂君，羊军，刘竹，陈唐葶，周小琳，张瑞，谭晓秋，雷鸣，欧贤红*.光学标测技术评价异丙肾上腺素诱导的应激性心肌病小鼠心脏电活动. 中华老年心脑血管病杂志,2022,24(4): 412-417
13. Binbin Yang#, Qin Jiang#, Shicheng He, Tao Li, Xianhong Ou, Tangting Chen, Xuehui Fan, Feng Jiang, Xiaorong Zeng, Christopher L-H Huang, Ming Lei*, Xiaoqiu Tan*. Ventricular SK2 upregulation following angiotensin II challenge: modulation by p21-activated kinase-1. Journal of Molecular and Cellular Cardiology,2021, 10:S0022-2828(21)00210-8.
14. Yu W, Ou X, Liu X, Zhang S, Gao X, Cheng H, Zhu B, Yan J. ACE2 contributes to the maintenance of mouse epithelial barrier function. Biochem Biophys Res Commun. 2020,533(4):1276-1282. IF 3.1
15. Grassam-Rowe A, Ou X, Lei M. Novel cardiac cell subpopulations: Pnmt-derived cardiomyocytes. Open Biol. 2020 Aug;10(8):200095.
16. O'Shea C, Holmes AP, Winter J, Correia J, Ou X, Dong R, He S, Kirchhof P, Fabritz L, Rajpoot K, Pavlovic D. Cardiac optogenetics and optical mapping - overcoming spectral congestion in all-optical cardiac electrophysiology. Frontiers in physiology. 2019;10:182
17. He S#, Wen Q#, O'Shea C#, Mu UMR#, Kou K, Grassam-Rowe A, Liu Y, Fan Z, Tan X, Ou X*, Camelliti P*, Pavlovic D*, Lei M*. A protocol for transverse cardiac slicing and optical mapping in murine heart. Frontiers in physiology. 2019;10:755
18. Fan X, Sun T, Crawford W, Tan X, Ou X, Terrar DA, Ebert SN*, Lei M*. Pnmt-derived cardiomyocytes: Anatomical localization, function and future perspectives. Frontiers in physiology. 2019;10:713
19. Dong R#, Mu-u-min R#, Reith AJM#, O’Shea C#, He S, Duan K, Kou K, Grassam-Rowe A, Tan X, Pavlovic D, Ou X*, Lei M*. A protocol for dual calcium-voltage optical mapping in murine sinoatrial preparation with optogenetic pacing. Frontiers in physiology. 2019;10
